Allergy Testing

ALEX Allergy Test (IgE Blood Test)

The new ALEX test (Macro-Array Diagnostics, of Vienna, Austria) comprises 126 component allergens plus 156 native allergens. That is therefore 282 tests in total, covering 167 different natural allergens (more than 150 allergen extracts and more than 100 molecular allergens – pollen, mold, fungus associated with atopic dermatitis and other skin diseases – mites, pets, insects and a range of foods), supplemented with total IgE, ALEX ® can cover over 99% of the need for routine allergy diagnosis).

This much greater allergen panel is therefore not only useful for researching individual allergens for individual patients but is also a comprehensive and definitive allergen screening test for suspected allergic patients.

After a decade of use, the ISAC test is available within the NHS and from private laboratories for private practice Allergy Consultants. The very recently introduced ALEX test is so far available from a commercial service but will become available on the NHS soon. ALEX ® Allergy Explorer is the first and most scientifically advanced in vitro multiplex allergy test allowing simultaneous measurement of total IgE (tIgE) and specific IgE (sIgE) against a plethora of allergen extracts and molecular allergens. Based on our test panels composition of allergen extracts and molecular allergens, a near complete picture of each patient’s sensitization status is obtained. ALEX ® is based on our proprietary nano-bead technology. ALEX ® is the new generation gold standard of in vitro tests for Type I allergies.

These component lgE antibody screening tests are very useful in people who suffer with multiple food and inhalant allergies and helps identify to which group or groups of allergen they are cross reacting such as profilins, LTPs, Tropomycins or CCDs. Once their cross- reactive allergen groups are identified, one can predict severity of future reactions and whether they would benefit from desensitization immunotherapy.

The ALEX ® assay protocol integrates a powerful Cross-reactive Carbohydrate Determinants (CCDs) inhibitor during serum incubation, which will clear up your specific IgE results. This increases the specificity of our test results.